Cancer is the cause of an increasing number of deaths in the world and the effectiveness of its treatment is largely dependent on stage of disease at the time of diagnosis. Cancer prevention may be based on the use of bioactive compounds of plant origin, including Cruciferae. Cruciferous vegetables have a high content of glucosinolates, polyphenols, vitamin C, carotenoids, and minerals. The aim of our research is to compare the effectiveness of the antitumor activity of young shoots o red cabbage in relation to vegetable at full maturity. In addition, we want to show the mechanisms responsible for programmed death of prostate cancer cells line DUXNUMX and LNCaP. The project plan involves interdisciplinary research in the field of nutrigenomics and a comprehensive examination of the juice from young shoots of and red cabbage, as a source of bioactive substances. The aims of this project will be implemented in separate tasks that include: • analytic studies to determine and compare the basic composition and content of bioactive compounds in young shoots of red cabbage and in vegetable at full maturity, • in vitro research on human prostate cancer cell lines to determine the cellular mechanisms responsible for the reduction of their viability under the influence of juice after in vitro digestion and absorption in the model of the gastrointestinal tract.
Supplying bioactive compounds with the daily diet is an important factor in cancer prevention. Young shoots of red cabbage, which are in the phase of intensive growth, may be rich in bioactive compounds. In the literature, there is data on the health promoting properties of individual compounds contained in cruciferous vegetables at full maturity. Antitumor properties of isothiocyanates as degradation products of glucosinolates are well described. This approach, from a nutritional point of view, does not take into account the mutual interfering of components, involving inhibiting or enhancing the antitumor activity. The obtained results can be used for continuation of this project in vivo on experimental animals and in the final stage involving humans. The authors of the project assume the possibility of developing and introduction to the production of dietary supplements based on the product tested in this project, as well as other product of plant origin tested in parallel.
University of Agriculture in Krakow
I am PhD student in the Department of Human Nutrition and Dietetics, Faculty of Food Technology, University of Agriculture in Krakow. I implement its own research project: “Antitumor activity of young shoots of red cabbage (Brassica oleracea var. capitata f. rubra) in relation to prostate cancer cells measured by the proliferation, apoptosis and cell cycle analysis”, financed by the National Science Center.Brassica oleracea there. capitata f. rubra) relative to prostate cancer cells, measured by proliferation index, apoptosis and cell cycle analysis. "