Galanthamine is used for Alzheimer’s disease treatment as an acetylcholinesterase inhibitor. Nowadays, there are two ways for a wide-scale production of this compound: extraction from natural sources such as Amaryllidaceae bulbs and total chemical synthesis. Both methods have considerable disadvantages, such as low effectiveness or relatively high cost. What is important, the Alzheimer’s disease prevalence rate is increasing rapidly year by year, and so the demand for galantamine. According to the WHO data, the number of Alzheimer’s patients in 2030 will reach 66 million and in 2050 – even 115 million.
As of today, there is no alternative to the currently used methods for galanthamine production. Therefore, developing new ways for the biosynthesis of this compound would be of great value to the pharmaceutical industry. Here, we would like to present a novel procedure for galanthamine production which is based on in vitro cultures optimized for faster biomass increase and higher galantamine content. The method is validated for laboratory-scale use.
Planned activities are focused on finding a partner that would facilitate access to a laboratory, help to perform industrial-scale method scale-up, as well as support protection of the method with intellectual property rights.
The offer is addressed for representatives of the pharmaceutical industry interested in developing the proposed procedure of galantamine production in cooperation with the academic environment.
Presenter: Emilia Morańska, University of Agriculture in Krakow
I am a biotechnologist and I am currently completing my doctoral studies at the University of Agriculture in Krakow. My research at the Department of Plant Breeding, Physiology and Seed Production of the Faculty of Agriculture and Economics focuses on the biosynthesis of Amaryllidaceae alkaloids in in vitro cultures. The area of my scientific interests also includes bioinformatics and genome analysis.
Abstract authors: Emilia Morańska, Agata Ptak, Magdalena Simlat
Department of Plant Breeding, Physiology and Seed Science, Faculty of Agriculture and Economics