Respiratory markers for the early diagnosis of chronic kidney disease

The aim of the presented project is to broaden the knowledge about the possibility of using volatile organic compounds (VOCs) detected in exhaled air in the diagnosis of chronic kidney diseases (CKD) and comorbidities. In our research, we want to confirm the diagnostic usefulness of selected compounds. All tests will be performed using a gas chromatograph with a mass spectrometer. We are interested in cooperation to develop a sensor that detects those compounds that have been selected as potential markers of CKD and concomitant diseases during our chromatographic analyzes.

Research into diagnostic non-invasive tests is particularly important for asymptomatic diseases. CKD is one of the diseases that are often diagnosed too late when complications or comorbidities (diabetes, cardiovascular diseases, neurological complications) occur. Currently, CKD is recognized as a global health problem.

To date, we have selected two compounds that should be useful in monitoring the treatment of patients with CKD or in monitoring the correctness of dialysis. We estimate that the time it takes to prepare and launch the kidney disease sensor can take four years.

The development of a diagnostically useful breathing test requires determining whether there are statistically significant differences between the breathing profiles in the control group and in the group diagnosed with the disease. Therefore, it is planned to conduct respiratory profile tests in the renal function control group and in the patient group. Both groups of respondents will be properly selected in terms of age and sex.

In our previous studies, in order to compare the differences between the concentrations of selected volatile organic compounds (VOCs) in the breathing of both groups, a non-parametric Mann-Whitney test was used. Part of the detected compounds differed statistically significantly with the concentrations in both examined groups.

Our analytical experience gained in previous studies should ensure good implementation of the proposed project. We hope that our initial test results will be sufficient to build a prototype sensor for CKD detection.

If you have kidney problems, you need to be diagnosed and treated early to prevent the so-called end-stage renal disease. Breath tests seem to be a promising diagnostic tool that will allow early non-invasive detection of this condition.

Meet the presenter: Beata Grabowska-Polanowska, assistant professor at the Institute of Nuclear Physics PAS

E: beata.grabowska ifj.edu.pl

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